ABSTRACT
Background: Type 2 Diabetes mellitus (T2DM) is the most common non-communicable chronic diseases in developed and developing countries around the world. The study reported the prevalence of diabetes association with rheumatoid arthritis (RA) among different obese and non-obese populations of Patna, India.Methods: This clinic based descriptive study was conducted in Patna city from 1st August 2017 to 30th September 2018. A total 250 patients with diagnosed RA were enrolled. DM was defined according to the ADA recommendations as FBS ≥126mg/dl or oral glucose tolerance test OGTT2 ≥200mg/dl and HbA1c≥6.5. On the basis of the BMI calculated, patients were categorized either as obese or non-obese. Random diabetic detection was done to detect T2DM and followed by proper investigation at clinical laboratories. Patients also asked for hyperglycemic events during initial counselling.Results: Mean BMI in obese was found to be 29.22±3.22 and in non-obese it was 22.99±1.38 (p<0.001). Most of the patients had been type 2 diabetes for more than 5 years duration. In both genders, an increasing trend was observed in the prevalence of type 2 diabetes with increasing BMI. Among these, a total of 198 (79.2%) were found to have diabetes, 115 (58.08%) of these were obese and 83 (41.91%) non-obese (p=0.003).Conclusions: BMI is directly correlated to type 2 diabetes, as T2DM was significantly more common in obese patients with RA compared to non-obese patients with RA. Obese patients with RA had significantly more frequent diabetes.
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Background: This study aimed to assess the prevalence of prediabetes using glycated hemoglobin (HbA1c) in above 40 years age group health care professional in Patna.Methods: This was a cross sectional study carried out amongst 315 employees of the Independent Public Central Hospital in Patna. The selection of healthcare professionals for the study was random. The largest study subgroup (63.4%) were nurses, followed by word attender (13.5%), other administrative employee (10.3%), and orderlies (6.6%). All subjects underwent glycated hemoglobin level measurement at hospital laboratory. Data were analysed using descriptive statistics, chi-square and binary logistic regression tests at value of p <0.05.Results: The study group was evaluated for prediabetes (expressed in the form of HbA1c levels) with an American Diabetes Association-approved classification. The results indicated that a vast majority of the evaluated healthcare personnel (383 people; 82.4%) had normal glycated hemoglobin levels. The remainder of the study group showed carbohydrate metabolism disturbances. The range of glycated hemoglobin levels (5.7-6.4%) found in 73 people (15.7%) suggested an increased risk for diabetes. As a result of the study, as few, or as many, as 9 people (1.9%) were diagnosed with diabetes (initial diagnosis).Conclusions: These results emphasize the need to develop an urgent public program to improve the detection, prevention, and treatment of diabetes. Most of the evaluated healthcare professionals (79.36%) showed no evidence of being at risk for type 2 diabetes mellitus. Only 17.6% of respondents were unaware of their metabolic disturbances. The study demonstrated a positive correlation between body mass index values and glycated hemoglobin levels in the evaluated group of healthcare professionals (R=0.3), which was similar to that found in the general population.
ABSTRACT
As our age advances, many changes are seen in our body, such as cellular changes, cardiovascular problems, cerebrovascular diseases, including cancer mediated by inflammation and their mediators such as free radicals (ROS, RNS), cytokines, transcription factors (NF-KB, STAT3) due to altered dietary patterns and digestive disorders. The disease pattern can be suppressed by including anti-inflammatory dietary supplements in our diet to prevent various diseases in geriatric peoples associated with inflammation. Chronic activation of the inflammatory response, defined as inflammation, is the key physio-pathological substrate for anabolic resistance, sarcopenia and frailty in older individuals. Nutrients can theoretically modulate this phenomenon. This article briefs about anti-inflammatory dietary supplements in prevention of diseases associated with inflammation in geriatric people.